ABSTRACT
To find a cure for Covid-19 has been a constant struggle, and one field that goes unexplored is the possibility of using fungal metabolites as a remedy. As fungal metabolites are known to showcase a wide range of biological activities, with this set insight, the present research goes on to explore fungal metabolites as a means to find a drug for treating Covid-19. WithIP: protease182.75.148.10enzyme On: asThu,the 07 mainApr focus,2022 many14:16:09antiviral compounds/metabolites from various fungal species were screened, then made to udergo various in Silico activities. In this study, 18 Copyright: American Scientific Publishers fungal metabolites with antiviral properties were extracted from the antibiotic database and then put through Delivered by Ingenta molecular docking with the help of software such as AutoDock Vina and PyRx. The drug-likeness properties were analyzed using pkCSM. There were five likely chemicals against the Mpro enzyme of COVID-19, which are (Chromophilone I, iso, F13459, Stachyflin, acetyl, Chromophilone II, iso and A-108836). Molecular Dynamics simulations helped achieve a hit, Chromophilone I. Naturally obtained Phyto-compounds will help establish a dependable medication or support lead identification, which was achieved by utilizing existing strategies. In Vitro and in Vivo studies can be conducted to analyze further the effectiveness of the identified hit against Covid-19.
ABSTRACT
COVID-19 pandemic has infected more than 208 million people and accounted for more than 4.5 million deaths worldwide. In our present study, Najran university (NU) students’ knowledge, attitude and practice (KAP) towards COVID-19 was assessed using twenty, ten and eight-item scale questions respec-tively. Similarly, use of herbal and nutritional supplements to protect and cure against COVID-19 infections was measured including type, source of information and factors enforcing the use of such supplements. Addi-tionally, students shared their beliefs about immune enhancing potential of various nutritional components. SPSS package was used to perform statistical analyses. A total of 94 (67%) responses were obtained from male undergraduate pharmacy students. The students with good knowledge, positive attitude and proper practice towards COVID-19 were 29.6%, 85.2%, and 72.8%. respectively. Almost half of students used some herbal and nutritional supplements as protective measure against the COVID-19 infection. As forecasted, honey (34.6%), ginger (33.3%), and vitamin C (32.1%) were the most commonly used supplements. More than half students believe that using garlic (60.5%), black seeds (53.5%), citrus fruits (53.1%), and ginger tea (50.6%) will boost the immunity. Considering the fact that in-campus teaching has resumed in Saudi Arabian universities, amalgamate with peers would be common, hence adequate level of KAP towards COVID-19 is essential. Perhaps, getting COVID-19 vaccine shots are mandatory to attend in-campus classes in Saudi Arabia, still following precautionary measure are obligatory.